Education:

Ph.D. Student Department of Chemistry and Biochemistry (2003)
University of California, San Diego, La Jolla, CA
Advisor: Professor Stanley J. Opella
Thesis: Novel Methods for the Application of Anisotropic Measurements to Membrane Protein Structure Determination

M.S. Department of Chemistry (2000)
University of Pennsylvania, Philadelphia, PA
Advisor: Professor Stanley J. Opella

Research Scientist. Lawrence Livermore National Laboratory (1997 - 1998)
Advisors: Dr. M. Cosman (LLNL) / Dr. C. Genain (UCSF)
Cloning, expression, purification, and molecular modeling of Myelin Oligodendrocyte Glycoprotein. Solution NMR and activity-based modeling.

B.A. Integrated Science Program, Chemistry (1997)
Northwestern University, Evanston, IL

Publications:

1. Nevzorov, A.A., Mesleh, M.F., Opella, S.J. NMR and Structure Determination of Aligned Samples of Membrane Proteins. Magnetic Resonance in Chemistry, In Press, 2003

2. Park, S.H., Mrse, A.A., Nevzorov, A.A., Mesleh, M.F., Oblatt-Montal, M., Montal, M., Opella, S.J. Three-dimensional structure of the channel-forming trans-membrane domain of the Virus protein 'u' (Vpu) from HIV-1. Journal of Molecular Biology, In Press, 2003.

3. Mesleh, M.F. and Opella, S.J. Dipolar Waves as Maps of Helices in Proteins. Journal of Magnetic Resonance, 2003 163(2) 288-299.

4. Mesleh, M.F., Lee, S., Veglia, G., Thiriot, D.S., Marassi, F.M., Opella, S.J. Dipolar Waves Map the Structure and Topology of Helices in Membrane Proteins. Journal of the American Chemical Society, 2003 125(29), 8928-8935.

5. Lee, S., Mesleh, M.F., Opella, S.J. Structure and Dynamics of a Membrane Protein with Three Experiments. Journal of Biomolecular NMR, 2003 26(4), 327-334.

6. Valentine, K.G., Mesleh, M.F., Ikura, M., Ames, J.B., Opella, S.J. Structure Topology and Dynamics of Myristoylated Recoverin Bound to Phospholipid Bilayers. Biochemistry, 2003 42(21), 6333-6340.

7. Zeri, A.C., Mesleh, M.F., Nevzorov, A.A., Opella, S.J. Structure of the coat protein of fd filamentous bacteriophage particles. Proceedings of the National Academy of Sciences USA, 2003 100(11), 6458-6463.

8. Mesleh, M.F., Valentine, K.G., Lewis, J.M., Gronenborn, A.M., Opella, S.J. Myristoylation as a General Method for Immobilization and Orientation of a Protein for Structure Determination by Solid-State NMR Spectroscopy. Journal of Biomolecular NMR, 2003 25(1), 55-61.

9. Opella, S.J., Nevzorov, A.A., Mesleh, M.F., Marassi, F.M. Structure Determination of Membrane Proteins by NMR Spectroscopy. Biochemistry and Cell Biology, 2002 80(5), 597-604.

10. Mesleh, M.F., Veglia, G., DeSilva, T.M., Marassi, F.M., Opella, S.J. Dipolar Waves as NMR Maps of Protein Structure. Journal of the American Chemical Society, 2002 124 (16), 4206-4207.

11. Mesleh, M.F., Belmar, N., Krishnan, V.V., Maxwell, R.S., Genain, C P., Cosman, M. Marmoset Fine B-Cell and T-Cell Epitope Specificities Mapped onto a Homology Model of the Extracellular Domain of Human Myelin Oligodendrocyte Glycoprotein Reveals Potential Sites of Antibody Binding. Neurology of Disease, 2002 9 (2), 160-172.

12. Thornton, K.M., Krishnan, V.V., Mesleh, M.F., Genain, C.P., Cosman, M. Three Dimensional Structure of the Extracellular Domain of Myelin Oligodendrocyte Glycoprotein. Manuscript in Preparation.

13. Genain, C.P., Thornton, K.M., Krishnan, V.V., Mesleh, M.F., Cosman, M. Structural Plasticity of a Protein Implicated in the Immunopathogenesis of Multiple Sclerosis. Annals of Neurology, 1999 46 (6), 936.

14. Mesleh, M.F., Hunter, J.M., Shvartsburg, A.A., Schatz, G.C., Jarrold, M.F. Structural information from ion mobility measurements: Effects of the long-range potential. Journal of Physical Chemistry, 1996 100 (40), p16082-16086.

15. Wang, X.K., Lin, X.W., Mesleh, M.F., et al., The Effect of Hydrogen on the Formation of Carbon Nanotubes and Fullerenes. Journal of Materials Research, 1995 10(8) 1977-1983.