Contact Information:

Department of Chemistry and Biochemistry
University of California, San Diego
Natural Science Building, Room 3113
9500 Gilman Drive, MC 0307
La Jolla CA 92093-0307 USA

TEL: (858)-822-4707
FAX: (858) 822-4821
email: filipp [-at-] ucsd.edu

Education:

Postdoc Opella lab, UCSD (2007)

Postdoc EMBL Heidelberg, Sattler lab, EMBL (2006)

Joint Ph.D. / Dr. rer. nat EMBL Heidelberg and University of Heidelberg "NMR Studies of Molecular Recognition and Dynamics in Peroxisomal Import" (2006)

M.Sc. University Heidelberg, Germany Sattler lab, EMBL Hamburg, Collaboration with Wilmanns lab, EMBL Outstation Hamburg (2002)

Research internship, Weizmann Institute of Science, Israel Department of Biological Chemistry, Wallach lab Supported German National Academic Foundation (2000)

Biochemistry / Biophysics study, Universities of Regensburg and Heidelberg (1997)

Abitur, Feodor-Lynen-Gymnasium, Planegg (Munich), Germany (1996)

Research interests:

• Biophysics and structural biology
  
• solution and aligned sample solid-state NMR spectroscopy
  
• Structure and dynamics of biological macromolecules
  
• Molecular recognition in multi-component complexes
  
• Structure based drug design and membrane proteins

Research focus:

The lifecycle of the many pathogens is intimately associated with membranes. Infections include recognition of the cellular envelope, fusion with susceptible cells and often end with budding of new infectious particles. The focus of my studies is to develop structural pictures of integral membrane proteins involved in infections, resolve their interactions and design drugs interfering with the pathogenic process.

Publications:

11. Black SL, Stanley WA, Filipp FV, Bhairo M, Verma A, Wichmann O, Sattler M, Wilmanns M, Schultz C. Probing lipid and drug binding domains with fluorescent dyes. Bioorganic and Medicinal Chemistry, 2008 Feb 1;16(3):1162-73.

10. Sinha N, Filipp FV, Jairam L, Park SH, Bradley J, Opella SJ Tailoring 13C labeling for solid state NMR experiments on aligned samples of proteins. Magnetic Resonance in Chemistry, 2007 Dec; 45(S1): 107-115.

9. Filipp FV, Sattler M Conformational plasticity of the lipid transfer protein SCP2. Biochemistry. 2007 Jul 10; 46(27):7980-91.

8. Filipp FV From bench to bedside. An interview with Alain Fischer, immunologist and gene therapist at the Necker Hospital in Paris, France. EMBO Rep. 2007 May;8(5):429-32.

7. Filipp FV Is science killing sport? Gene therapy and its possible abuse in doping. EMBO Rep. 2007 May;8(5):433-5.

6. Stanley WA, Filipp FV,Kursula P,Erdmann R,Schliebs W, Sattler M, Wilmanns M Recognition of a functional peroxisome type 1 target by the dynamic import receptor Pex5p Mol Cell. 2006 Dec; 24(5):1000-10.

5. Mapelli M, Filipp FV, Rancati G, Massimiliano L, Nezi L, Stier G, Hagan RS, Confalonieri S, Piatti S, Sattler M and Musacchio A Determinants of conformational dimerization of Mad2 and its inhibition by p31comet EMBO J, 2006 Mar 22;25(6):1273-84.

4. Stanley WA, Filipp FV, Kursula P, Svergun DI, Sattler M, Wilmanns M. Receptor recognition by the flexible peroxisomal targeting signal type 1 of sterol carrier protein 2. Acta Cryst. March 2004: A60, S175

3. Peng C, Unger SW, Filipp FV, Michael Sattler M, Szalma S. Automated evaluation of chemical shift perturbation spectra: New approaches to quantitative analysis of receptor-ligand interaction NMR spectra. J Biomol NMR. 2004 Aug;29(4):491-504.

2. Filipp FV*, Douangamath A*, Klein ATJ, Barnett P, Zou P, Voorn-Brouwer T, Vega MC, Mayans OM, Sattler M#, Distel B, Wilmanns M#. Topography for independent binding of a-helical and PPII-helical ligands to a peroxisomal SH3 domain. Mol Cell. 2002 Nov;10(5):1007-17.
* Equally contributing authors, # Corresponding authors

1. Douangamath A, Filipp FV, Mayans OM, Vega MC, Barnett P, Sattler M, Distel B, Wilmanns M. Structural Studies of a dual ligand binding SH3 domain in Pex13p. Acta Cryst. 2002 Aug: A58, C286.

Links:

University of California, San Diego
http://www.ucsd.edu

EMBL Heidelberg
http://www.embl.org/

EMBO Heidelberg
http://www.embo.org/

EMBO reports, Nature Publishing Group
http://www.nature.com/embor/

University of Heidelberg
http://www.uni-heidelberg.de/

German National Academic Foundation
http://www.studienstiftung.de/

Koerber Foundation
http://www.koerber-stiftung.de/

International EMBL PhD symposium
http://phdsymposium.embl.org/

EMBL newsletter etcetera
http://www.embl.org/aboutus/news/publications/newsletter/

EICAT, EMBL International Center of Advanced Training
http://www-db.embl.de/jss/EmblGroupsOrg/g_286.html